Blood Physiology 1

57 %
43 %
Information about Blood Physiology 1

Published on August 8, 2007

Author: rtrafaelmd

Source: slideshare.net

Description

Blood Physiology: General Consideration; Plasma; Cellular Elements of the Blood

Blood Physiology Rodolfo T. Rafael, M.D.,CFP http://clinical-updates.blogspot.com [email_address] +639212147558

Blood Physiology General Consideration Plasma Cellular Elements of the Blood

General Consideration

Plasma

Cellular Elements of the Blood

 

General Consideration unicellular organisms nutrition and excretion volume of the extracellular environment greatly exceeds that of the cell multicellular organisms specialized tissue

unicellular organisms

nutrition and excretion

volume of the extracellular environment greatly exceeds that of the cell

multicellular organisms

specialized tissue

Unicellular Organism

Functions of the Blood homeostasis respiratory function nutritive function excretory function transport internal secretions helps maintain acid-base balance maintenance of water and electrolyte imbalance and in regulation of colloid and total osmotic pressure immunity to disease and protect the body against bacteria regulation of the body temperature

homeostasis

respiratory function

nutritive function

excretory function

transport internal secretions

helps maintain acid-base balance

maintenance of water and electrolyte imbalance and in regulation of colloid and total osmotic pressure

immunity to disease and protect the body against bacteria

regulation of the body temperature

Composition of the Blood Plasma Formed Elements

Plasma

Formed Elements

Plasma Water Plasma proteins Blood sugar Lipids Inorganic salts Special Plasma Substances Gases

Water

Plasma proteins

Blood sugar

Lipids

Inorganic salts

Special Plasma Substances

Gases

Water 91-92%

91-92%

Plasma Proteins liver albumin, globulin, fibrinogen, and prothrombin Function maintenance of water balance Imparts a viscosity to the blood sources of antibodies blood clotting maintain acid-base balance

liver

albumin, globulin, fibrinogen, and prothrombin

Function

maintenance of water balance

Imparts a viscosity to the blood

sources of antibodies

blood clotting

maintain acid-base balance

Blood Sugar glucose source of energy

glucose

source of energy

Lipids neutral fats, cholesterol, and phospholipids supply energy or stored as fat

neutral fats, cholesterol, and phospholipids

supply energy or stored as fat

Inorganic Salts Calcium ions and the Sodium ions Salt ions (chlorides, bicarbonates, phosphates, sulfates) Electrolytes (sodium, calcium, potassium, and magnesium) Calcium ions and phosphates Iodides and Iron

Calcium ions and the Sodium ions

Salt ions (chlorides, bicarbonates, phosphates, sulfates) Electrolytes (sodium, calcium, potassium, and magnesium)

Calcium ions and phosphates

Iodides and Iron

Special Plasma Substances hormones enzymes clotting elements antibodies urea uric acid creatinine

hormones

enzymes

clotting elements

antibodies

urea

uric acid

creatinine

Gases oxygen carbon dioxide nitrogen

oxygen

carbon dioxide

nitrogen

Formed Elements Red Cell or Erythrocytes WBC or Leucocytes Blood Platelets or Thombocytes

Red Cell or Erythrocytes

WBC or Leucocytes

Blood Platelets or Thombocytes

Red Blood Cell Description Normal Values Red Cell Production Red Blood Cell Destruction Osmotic Fragility Function of Erythrocytes

Description

Normal Values

Red Cell Production

Red Blood Cell Destruction

Osmotic Fragility

Function of Erythrocytes

Description biconcave discs, 2µm thick 8 μ m in diameter deformable (PGE 1 , PGE 2 ) carry hemoglobin in circulation 1 liter- 3ml of dissolved O 2 hemoglobin can transport 70 times this amount 20 ml of O 2 = 100ml of blood non- nucleated

biconcave discs, 2µm thick 8 μ m in diameter

deformable (PGE 1 , PGE 2 )

carry hemoglobin in circulation

1 liter- 3ml of dissolved O 2

hemoglobin can transport 70 times this amount

20 ml of O 2 = 100ml of blood

non- nucleated

 

 

 

Normal Values Men 5-6 x 10 12 /L of blood Women 4-5 x 10 12 /L of blood Infants 6.5 x 10 12 /L of blood Hemoglobin 120- 150g/L (female) 140-170g/L (male) Erythrocyte (Hct) 0.38- 0.48 (female) 0.40- 0.50 (male)

Men 5-6 x 10 12 /L of blood

Women 4-5 x 10 12 /L of blood

Infants 6.5 x 10 12 /L of blood

Hemoglobin

120- 150g/L (female)

140-170g/L (male)

Erythrocyte (Hct)

0.38- 0.48 (female)

0.40- 0.50 (male)

Red Cell Production yolk sac of the embryo few weeks liver, spleen, lymph node middle trimester bone marrow of skull, vertebrae, ribs, sternum later part of pregnancy

yolk sac of the embryo

few weeks

liver, spleen, lymph node

middle trimester

bone marrow of skull, vertebrae, ribs, sternum

later part of pregnancy

Erythropoiesis Hemocytoblast basophil erythroblast polychromatophil erythroblast normoblast reticulocyte erythrocytes

FeedBack Control inhibited supernormal level stimulated anemia hypoxemia controlled erythropoetin

inhibited

supernormal level

stimulated

anemia

hypoxemia

controlled

erythropoetin

Hypoxemia kidney liver REF Globulin Erythropoietin Stem cells Erythrocytes

Red Blood Cell Destruction Life span 120 days Destruction 2.5M/sec 1% of red cells/day Spleen Mechanical and Chemical stresses friction

Life span

120 days

Destruction

2.5M/sec

1% of red cells/day

Spleen

Mechanical and Chemical stresses

friction

Osmotic Fragility hypertonic solution hypotonic solution isotonic solution Fragility Index 0.45-0.38% NaCL 0.36- 0.30% NaCl

hypertonic solution

hypotonic solution

isotonic solution

Fragility Index

0.45-0.38% NaCL

0.36- 0.30% NaCl

Primary Function of Erythrocytes transport hemoglobin carries oxygen carbon dioxide

transport hemoglobin

carries oxygen

carbon dioxide

White Blood Cell Description Classes of Leucocytes Normal Values Origin Life span Function of Leucocytes

Description

Classes of Leucocytes

Normal Values

Origin

Life span

Function of Leucocytes

Description nucleated

nucleated

 

Classes of Leucocytes non-granular lymphocytes monocytes granular neutrophils basophils eosinophils

non-granular

lymphocytes

monocytes

granular

neutrophils

basophils

eosinophils

Normal Values WBC 5-10 x 10 9 /L of blood basophils 0.005 eosinophils 0.02-0.04 stabs 0.02 – 0.04 segmenters 0.45- 0.65 lymphocytes 0.20- 0.35 monocytes 0.02- 0.06

WBC 5-10 x 10 9 /L of blood

basophils 0.005

eosinophils 0.02-0.04

stabs 0.02 – 0.04

segmenters 0.45- 0.65

lymphocytes 0.20- 0.35

monocytes 0.02- 0.06

Origin granular red bone marrow non- granular lymphatic tissue (lymph nodes, tonsils, payer’s patches, spleen and thymus)

granular

red bone marrow

non- granular

lymphatic tissue (lymph nodes, tonsils, payer’s patches, spleen and thymus)

Life span Granulocytes two weeks Large lymphocytes 2-3 days small ones 100-200 days

Granulocytes

two weeks

Large lymphocytes

2-3 days

small ones

100-200 days

Function of Leucocytes Neutrophils phagocytic Lymphocytes non phagocytes immune reactions antibodies tissue transplant Monocytes phagocytic combating chronic infection

Neutrophils

phagocytic

Lymphocytes

non phagocytes

immune reactions

antibodies

tissue transplant

Monocytes

phagocytic

combating chronic infection

Monocytes arrive at the site of infection few organelles form these organelles small granules rough endoplasmic reticulum ribosomes synthesize enzymes used to digest material ingested by monocytes

Eosinophils phagocytic allergic reaction Antibody react with antigen inactivate it eosinophil gets rid of inactivated complex

phagocytic

allergic reaction

Basophils heparin phagocytes

heparin

phagocytes

Blood Platelets Description Normal Values Origin Life span Functions

Description

Normal Values

Origin

Life span

Functions

Description small colorless bodies 2-4 microns in diameter

small

colorless bodies

2-4 microns in diameter

Normal Values 200-400 x 10 9 /L thrombocytopenia

200-400 x 10 9 /L

thrombocytopenia

Origin megakaryocytes

megakaryocytes

 

Life Span 4-5 days

4-5 days

Function white thrombus or a platelet plug thromboplastin  essential for blood coagulation Serotonin Helps in clot retraction

white thrombus or a platelet plug

thromboplastin  essential for blood coagulation

Serotonin

Helps in clot retraction

Platelet Aggregation occurs before clotting agglutination on platelets depend on several factors: rate of flow size of the blood vessel character of the vessel wall presence of ADP

occurs before clotting

agglutination on platelets depend on several factors:

rate of flow

size of the blood vessel

character of the vessel wall

presence of ADP

P A ADP Acts as local hormone Cause rapid platelet aggregation Calcium Platelet Adhere +

 

Thank You! For Not Listening

Add a comment

Related pages

BLOOD PHYSIOLOGY PART 1 ANAESTHESIA TUTORIAL OF THE WEEK 222

ATOTW 222 – Blood Physiology – part 1 09/05/2011 Page 1 of 8 ... This is the first of two tutorials on blood physiology for the anaesthetist.
Read more

Human Physiology/Blood physiology - Wikibooks, open books ...

Human Physiology/Blood physiology. From Wikibooks, open books for an open world < Human Physiology. ... Less than 1% of whole blood consists of platelets.
Read more

Blood Physiology - YouTube

Blood Physiology rnhoski. Subscribe Subscribed Unsubscribe 1,419 1K. Loading ... Blood, Part 1 - True Blood: Crash Course A&P #29 - Duration: 10:00.
Read more

BLOOD PHYSIOLOGY - Faculty Website Directory - Community ...

BLOOD PHYSIOLOGY . I Introduction. A. Composition. 1. formed elements. a.
Read more

Blood - Wikipedia, the free encyclopedia

Blood performs many important functions within the body including: Supply of oxygen to tissues (bound to hemoglobin, which is carried in red cells)
Read more

Blood Physiology - YouTube

Just wanted to post a less than 1 hour video covering blood physiology. This video covers the properties of whole blood and its components, as ...
Read more

Lecture: Physiology of Blood - FACULTY WEB PAGES: Los ...

Lecture: Physiology of Blood. I. Components, Characteristics, Functions of Blood. A. Major Components of Blood. 1. formed elements - the actual cellular ...
Read more