Blood clotting

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Information about Blood clotting

Published on March 10, 2014

Author: nirmalajosephine1



Blood Clotting

Blood Clotting

Blood cells involved Platelets + Clotting factors

Blood Clotting Factors Factor Number Common Name I II III IV Va VII VIII IX X XI XII XIII Fibrinogen Prothrombin Tissue Factor Ca2+ Proaccelerin Proconvertin Antihemophilic Factor Christmas Factor Stuart Factor Plasma thromboplastin antecedent Hageman factor Fibrin Stabilizing Factor

Process • Injury/ rupture to blood vessel • Blood vessel around wound constrict - reduce blood flow to the damaged area. • Activated Platelets stick to injury site • Platelets become sticky and clump together to form platelet plug. • Platelets & damaged tissue release clotting factors (eg.Factor VIII) • Blood clotting mechanism to form Fibrin which acts like a mesh to stop the bleeding.

Platelet activation also induces large morphological changes unactivated fully activated

Blood Clotting Mechanism

Scab Formation

Blood Clotting Videos • Blood Clotting Video 1 • Blood Clotting Video 2

Necessity For Blood Clotting • Prevent excessive blood loss • Prevent entry of micoorganisms through wound. Seals wound. • Maintain blood pressure

Consequences of Impaired Blood Clotting • No Factor VIII – Haemophilia – Blood clots slowly

Consequences of Impaired Blood Clotting • Blood clot (Thrombus) blocks artery (Thrombosis) • Thrombus dislodged & carried in blood flow (Embolus) • Embolus trapped in small artery & blocks blood flow (Embolism)

Consequences of Impaired Blood Clotting • Coronary artery partially blocked – chest pains (angina) If totally blocked – heart attack – death • Blockage of blood to brain cells – Stroke

Thrombosis & Embolism Video

Assignment - Flow Chart


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