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Information about biology, basic

Published on March 11, 2014

Author: hanipsych

Source: slideshare.net

Pharmacological Targets in Schizophrenia Dopamine Adapted from Kandel et al., eds. Principles of Neural Science. Norwalk, CT: Appleton & Lange; 1991:854. Hypoactivity: Negative and Cognitive Symptoms Hyperactivity: Positive Symptoms Tuberoinfundibular Pathway Mesocortical Pathway Mesolimbic Pathway Nigrostriatal Pathway Dopaminergic Pathways in the Brain

Schizophrenia Core Symptoms Psychotic Deficit Cognitive Positive Symptoms Mesolimbic pathway Negative Symptoms DLPC &VMPFC Cognitive Dysfunction DLPFC Affective VMPFC

Smith et al (1997) Synthesis and degradation of serotonin Tryptophan 5-Hydroxytryptophan (5- HTP) Tryptophan hydroxylase 5-Hydroxytryptamine (5- HT) 5-Hydroxytryptophan decarboxylase 5-Hydroxyindolacetic acid (5-HIAA) Monoamine oxidase (MAO)

Synthesis and degradation of catecholamines Phenylalanine Key COMT = Catechol O-methyltransferase MAO = Monoamine oxidase L-tyrosine Dopamine L-dopa Tyrosine hydroxylase 3-methoxy-tyramine Noradrenaline3,4-dihydroxyphenylacetic acid (DOPAC) Homovalinillic acid (HVA) 3-methoxy-4-hydroxy phenylglycol (MHPG) 3-methoxy-4-hydroxy mandelic acid (VMA)) COMT MAO MAO/COMT Roth et al (1995)

Synthesis and degradation of catecholamines Phenylalanine Key COMT = Catechol O-methyltransferase MAO = Monoamine oxidase L-tyrosine Dopamine L-dopa Tyrosine hydroxylase 3-methoxy-tyramine Noradrenaline3,4-dihydroxyphenylacetic acid (DOPAC) Homovalinillic acid (HVA) 3-methoxy-4-hydroxy phenylglycol (MHPG) 3-methoxy-4-hydroxy mandelic acid (VMA)) COMT MAO MAO/COMT Roth et al (1995)

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