BioImmobilizationTM For Medical Devices

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Information about BioImmobilizationTM For Medical Devices

Published on February 11, 2009

Author: paulrohricht



This presentation describes ICx\' BioImmobilizationTM technology and its application in medical device coatings.

Applications of ICx Protein-Polymer Composites: Medical Devices ICx BioImmobilization™ Vice President, Commercial Business Development

About ICx Technologies (NASDAQ: ICXT) Advanced sensor and technology development company Core business focus: military, homeland defense, security markets Founded 2003 25 entrepreneurial teams (companies) located in U.S., UK, Germany 800+ multi-disciplinary workforce. 200+ engineers, 50+ scientists Broad & diversified technology base: 35+ patents , 50+ filed Substantial government development funding 2008 Revenues: $175M Technologies developed within ICx have application outside of security: Wound care, in vitro diagnostics, medical devices We are actively engaged in seeking partnerships to commercialize products utilizing ICx technology and know-how Page 2

ICx-Agentase Agentase operates as a wholly-owned subsidiary of ICx (Pittsburgh, PA) Developing low-cost tools for the detection/decontamination of hazardous chemicals Technical expertise / IP Applied enzymology Formulation development Enzyme-polymer synthesis Urethanes – Fabrics – Gels – Films – Foams Acrylates Water-soluble protein-polymer conjugates – PEG-ylation – PEG-alternatives Scaled synthesis – Bench-top – Pilot – Production Rapid prototyping Launched commercial products based on our technology platform Page 3

ICx BioImmobilization™ ICx BioImmobilization™ Technology Proprietary immobilization of small molecules, enzymes and other proteins into a variety of polymers, covalently bonded within a growing polymer chain Biomolecules act as co-monomers in polymerization synthesis Applications In Vitro Diagnostics Wound healing: ‘smart’ bandages indicate healing progression, or can respond and deliver drugs in situ Medical device coatings: protein-polymer combinations can be pro- healing or can inhibit (anti-microbial, anti-thrombosis, anti-adhesion) Proteins can be immobilized within polymer foams and gels directly (eg., spinal implants) Versatility Polymers can be made into sprays, gels, or foams Pre-polymer material approved by FDA FDA approved and in use as hydrophilic dressings Page 4

ICx BioImmobilization™ Performance Loading of proteins, enzymes or other molecules into polymer allows target analytes to be detected at high sensitivity; Activity and specificity of biomolecules are well maintained for long periods through tertiary structure stabilization; Protein environmental and thermal sensitivity are dramatically reduced; Dyes can be simultaneously loaded into polymers to provide colorimetric indication of analyte presence (eg., wound progress indication); Covalent incorporation ensures molecules will not leach from polymers during use. Experience More than 100 proteins successfully immobilized; Multiple commercial products launched. Page 5

Enzyme Immobilization • Non-covalent immobilization (entrapment, adsorption) • Covalent attachment (typically single site attachment) + Enzyme covalently Enzyme Activated support immobilized • ICx BioImmobilization : Multiple and irreversible enzyme to matrix linkage TM ICx + Monomers TM BioImmobilization Enzyme Page 6

Applying BioImmobilization™ in healthcare Applications In Vitro Diagnostics Development of an analyte-specific sensor for point-of-care IVD Partners interested in working with us because of technology attributes Siemens RapidPoint TM – Stabilization of reagents and proteins » Shelflife: enzymes and reagents formulated to be stable for years without any special storage requirements » Operational: sensors perform reproducibly for long periods of time » Robust: work well under adverse and variable conditions Medical Devices and Wound Care Dressings Sensors – Identification – Qualification – Quantification Responsive, functional “smart” sponges, gels, materials, coatings, dressings Page 7

Biopolymers for Medical Device Coatings Convergence of drugs, devices, and polymers are creating new and innovative biomaterials TM ICx BioImmobilization can be used as a device coating for Accelerated healing and biocompatibility Decreased immunogenicity Protein eluting devices Antiseptic production in situ infection control Useful across a range of medical device products: Neurological (infusion catheters, hydrocephalic shunts, stroke treatment, embolic protection) Cardiovascular (coronary stents, guidewires, occlusion devices, catheters, heart valves, access systems) Oncology (microcatheters) Peripheral vascular (grafts, stents, imaging, closure devices) Ophthamology (access instruments) Cardiac Rhythm (CRT leads, implantable defibrillators, pacemaker leads, catheters and guidewires) Surgical (endoscopy accessories, obesity management, chest wound drainage) Urogenital (incontinance devices, penile implants, stents and catheters, contraceptive systems) Page 8

BioImmobilization™ for the development of ‘Smart’ Medical Device Coatings Potential to synthesize materials that respond to the physiological status in situ Analytical coatings Biosensors integrated within material coatings currently used in medical devices Markers for physiological condition at the site of device implantation Self-decontaminating coatings Utilize “decontaminating” enzymes to respond to detected high colony counts by producing disinfectants at the site of implantation Smart erodible materials Microenvironment responsive Potential delivery vehicle for actives – Anti-microbials, anti-adhesion, anti-thrombosis – Large MW drugs – Protein fragments – Prohealing factors (cytokines, growth factors) Actively seeking partnerships to exploit these concepts Page 9

Summary ICx has proprietary technologies that can be directly applied to the medical device coatings space BioImmobilization™ technology is able to incorporate active biomolecules and small molecules within biocompatible polymer foams, plugs, gels, and sprays We can use this technology to make advanced biomaterial coatings that can be used with medical devices Analytical devices Smart decontaminating materials Responsive materials ICx is actively seeking partnerships in wound care to exploit this know-how Page 10

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