Bio3 0910 Lec2 Controls Cd Ks

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Information about Bio3 0910 Lec2 Controls Cd Ks

Published on July 8, 2009

Author: kent


Cell Cycle Controls Biology 3 Kawashima Philippine Science High School SY 2009-2010

Key Terms and Concepts Checkpoints Cyclins Cyclin-dependent kinases

G1 Checkpoint Also known as “Restriction Point” in mammalian cells Cells that go through G1 usually complete the cell cycle Cells that do not receive the go-signal exit the cell cycle Quiescent non-dividing stage called G0 phase

G1 checkpoint Continue with G1 and proceed to S Exit cycle; switch to nondividing state

G2 Checkpoint MPF or maturation promoting factor drives the cell past the G2 checkpoint MPF is a protein complex composed of cyclins and cyclin-dependent kinases (Cdk) Accumulated cyclin in G2 associate with cyclin-dependent kinases

M Phase Checkpoint Ensures that chromosomes are properly attached to mitotic spindle (composed of microtubules) Anaphase promoting complex (APC) is inactive until kinetochores have interacted with microtubules Activation of APC indirectly triggers breakdown of cyclins

External Signals Affect Regulation

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