BIO 113- The Molecular Basis of Inheritance

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Information about BIO 113- The Molecular Basis of Inheritance

Published on October 1, 2008

Author: thefutureeducator


The Molecular Basis Of Inheritance : The Molecular Basis Of Inheritance Slide 2: The Discovery of the Molecular Basis Of Inheritance In the early 1900s, scientists knew that chromosomes, made up of DNA (deoxyribonucleic acid) and proteins, contained genetic information. However, they did not know whether the DNA or the proteins was the actual genetic material. In the 1940s, various researchers showed that DNA was the genetic material In the 1950s, the structure of DNA was determined. Slide 3: The DNA (Deoxyribonucleic Acid) The structure of DNA was determined by James Watson and Francis Crick in the early 1950s. DNA is a polynucleotide; nucleotides are composed of a phosphate, a sugar, and a nitrogen-containing base. The sugar in DNA is deoxyribose The four different bases in DNA are: adenine (A), thymine (T), guanine (G), and cytosine (C). Slide 4: A nucleotide Structure of DNA Slide 5: Watson and Crick showed that DNA is a double helix in which A is paired with T G is paired with C This is called complementary base pairing because a purine is always paired with a pyrimidine. Structure of DNA Slide 6: The DNA Double Helix Structure of DNA Slide 7: Structure of DNA Slide 8: Replication of DNA DNA replication occurs during chromosome duplication. An exact copy of the DNA is produced with the aid of DNA polymerase. Hydrogen bonds between bases break and enzymes “unzip” the molecule. Each old strand of nucleotides serves as a template for each new strand. New nucleotides move into complementary positions are joined by DNA polymerase. Slide 9: DNA replication Replication of DNA Slide 10: Ladder configuration and DNA replication Slide 11: Gene Expression A gene is a segment of DNA that specifies the amino acid sequence of a protein. Gene expression occurs when gene activity leads to a protein product in the cell. A gene does not directly control protein synthesis; instead, it passes its genetic information on to RNA, which is more directly involved in protein synthesis. Slide 12: RNA (ribonucleic acid) is a single-stranded nucleic acid in which A pairs with U (uracil) G pairs with C. Three types of RNA are involved in gene expression: messenger RNA (mRNA) carries genetic information to the ribosomes, ribosomal RNA (rRNA) is found in the ribosomes, transfer RNA (tRNA) transfers amino acids to the ribosomes, where the protein product is synthesized. The RNA (Ribonucleic Acid) Slide 13: Structure of RNA Slide 14: Two processes are involved in the synthesis of proteins in the cell: Transcription makes an RNA molecule complementary to a portion of DNA. Translation occurs when the sequence of bases of mRNA directs the sequence of amino acids in a polypeptide. Structure of RNA Slide 15: The Genetic Code DNA specifies the synthesis of proteins because it contains a triplet code: every three bases stand for one amino acid. Each three-letter unit of an mRNA molecule is called a codon. Most amino acids have more than one codon; there are 20 amino acids with a possible 64 different triplets. The code is nearly universal among living organisms. Slide 16: The Genetic Code Slide 17: The Amino Acids Amino acids are the building blocks of proteins. A protein forms via the condensation of amino acids to form a chain of amino acid "residues" linked by peptide bonds. There are 20 standard amino acids in a genetic code. These are: Phenylalanine Serine Leucine Tyrosine Cysteine Tryptophan Proline Histidine Glutamine Arginine Isoleucine Methionine Threonine Asparagine Lysine Valine Alanine Aspartate Glutamate Glycine Slide 18: Chemical Structures of Amino Acids 1. Phenylalanine 3. Leucine 4. Tyrosine 2. Serine Slide 19: 5. Cysteine 8. Histidine 6. Tryphophan 7. Proline Chemical Structures of Amino Acids Slide 20: Chemical Structures of Amino Acids 9. Glutamine 11. Isoleucine 12. Methionine 10. Arginine Slide 21: Chemical Structures of Amino Acids 13. Threonine 14. Asparagine 15. Lysine 16.Valine Slide 22: Chemical Structures of Amino Acids 17. Alanine 18.Aspartate 19. Glutamate 20. Glycine Slide 23: Central Concept or " The Central Dogma" The central concept of genetics involves the DNA-to-protein sequence involving transcription and translation. DNA has a sequence of bases that is transcribed into a sequence of bases in mRNA. Every three bases is a codon that stands for a particular amino acid. Slide 24: Overview of Gene Expression Slide 25: Overview of Gene Expression Slide 26: Transcription During transcription in the nucleus, a segment of DNA unwinds and unzips, and the DNA serves as a template for mRNA formation. RNA polymerase joins the RNA nucleotides so that the codons in mRNA are complementary to the triplet code in DNA. Slide 27: Transcription and mRNA Synthesis Slide 28: Translation Translation is the second step by which gene expression leads to protein synthesis. During translation, the sequence of codons in mRNA specifies the order of amino acids in a protein. Translation requires several enzymes and two other types of RNA: transfer RNA and ribosomal RNA. Slide 29: Review of Gene Expression DNA in the nucleus contains a triplet code; each group of three bases stands for one amino acid. During transcription, an mRNA copy of the DNA template is made. The mRNA is processed before leaving the nucleus. The mRNA joins with a ribosome, where tRNA carries the amino acids into position during translation. Slide 30: And that is our report on The Molecular Basis of Inheritance. Thanks for listening… ^_^

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