Autism powerpoint Romania-1

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Published on March 21, 2014

Author: akaroutis

Source: authorstream.com

THE USE OF ADIPOSE TISSUE STEM CELLS IN THE IMPROVMENT OF AUTISM: THE USE OF ADIPOSE TISSUE STEM CELLS IN THE IMPROVMENT OF AUTISM Autism and the related conditions are in increasing rates with males to suffer more frequently. Even though the early diagnosis and treatment help children socialize, each therapy is personalized. There is no common way of treatment. Causes of autism Genetic ? Environmental No Mutations Heavy metals related Vaccines ??? Brain Perfusion Immune system malfunction Brain Perfusion: Brain Perfusion Leads to nerve cell dysfunction Caused by heavy metals Glutamate competitor (Rizulole) used in clinical treatment ( http :// www . clinicaltrials . gov / ct / show / NCT 00251303? order =53 ) Potential: Turning stem cells to neuronal cells Immune System Malfunction: Immune System Malfunction Astrocytes: may produce increased amounts of inflammatory agents  nerve cells disfunction Reduced number of T-cells T-cell abnormalities B-cell abnormalities THERAPEUTICAL APPROACHES: THERAPEUTICAL APPROACHES Autologous hematopoietic stem cell CD34+ transplantation Mesenchymal stem cell transplantation to regulate the immune system Autologous hematopoietic stem cell CD34+ transplantation: Autologous hematopoietic stem cell CD34+ transplantation Goal: generation of new vessels in brain areas with reduced perfusion CD34+ stem cells: may secrete angiogenic factors that will turn into endothelial cells Stem cells from placenta perfusion: x10 more primitive endothelial cells than bone marrow No graft vs host reaction – Histocompatibility No moral issues – placenta would be cremated Mesenchymal stem cell transplantation to regulate the immune system : Mesenchymal stem cell transplantation to regulate the immune system Some children with autism may also have immune system abnormalities  Immune system regulation may improve brain function Mesenchymal stem cells have immunoregulatory activity Mesenchymal stem cell sources: Bone marrow 4. Dental pulp Skin 5. Adipose tissue Periosteum Mesenchymal cells – Immune System: Mesenchymal cells – Immune System Secret immunosupressive agents, eg. IL-10, TGF- β Act as antigen-presenting cells Suppress antigen recognition from T-cells Suppress dendritic cells maturation When transplanted with an allogenic transplant, mesenchymal cells help to avoid rejection (graft vs host reaction) Mesenchymal cells from Adipose Tissue: Mesenchymal cells from Adipose Tissue Adipose tissue: best source 100ml of adipose tissue result in millions of mesenchymal cells May be crypreserved for future use May be directly transplanted May be cultured and/or turned into other types of cells Mesenchymal cells from Adipose Tissue: Mesenchymal cells from Adipose Tissue Flow cytometry used for enumeration and viability results Sample tested for microbial contamination In case of contamination: culture may be decontaminated with specific antibiotics Via culture: reach even greater amounts of cells than those originally isolated Totally histocompatible with the patient More than one transplantations from only one liposuction/lipektomi Already used in clinical trials Clinical trials - Method: Clinical trials - Method 120 autistic children, age 2,5 y-20 y Psychologic, pediatric, psychiatric evaluation preceded Stem cells are administered i.v slowly in 150-250ml After 4 hrs monitoring the child is released Three months later readmission, reassessment of the child takes place, followed by new ASCs administration The procedure may be repeated 3 or 6 months later. Results: Results Evaluated parameters: socialization, improvement of relationship with other children and adults, minimization until disappearance of aggressiveness, discontinuation of self harm and improvement of cognitive function Clear improvement in 88% of the children: 54% showed significant improvement , 34% moderate improvement 80% of the children under the age of 8 years, began to speak 12% of the children, who have not become verbal, can write and answer at any question Conclusion : Conclusion Administration of autologous adipose tissue adult stem cells is a safe therapeutic approach offering a significant long term improvement of the clinical picture of autistic children Mesenchymal cells from adipose tissue already used for: : Mesenchymal cells from adipose tissue already used for: Breast reconstruction after mastectomy Tissue reconstructions after necrosis due to radiation Brain bone reconstruction after accident Crohn disease Allogenic transplantation of bone marrow Skin photoaging Aesthetic medicine Ischemic and haemorrhagic stroke Parkinson disease Diabetes Osteoarthritis and many more… Great potential of adipose derived mesenchymal stem cells: Great potential of adipose derived mesenchymal stem cells Thank you for your attention!

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