Assembly of Trabecular Bone Derived Scaffold Micro-Architectures for Patient Specific Applications, 10/2006
Information about Assembly of Trabecular Bone Derived Scaffold Micro-Architectures for...
Health & Medicine
Published on September 30, 2008
Poster presented to the Biomedical Engineering Society Conference, Chicago, IL 10/2006
Assembly Of Trabecular Bone Derived Scaffold Micro-Architectures
For Patient Specific Applications
M. Wettergreen, B. Bucklen And M. Liebschner
Rice University, Houston, TX
To improve upon the development of scaffolds for orthopedic tissue engineering purposes, we developed a library of architectures (unit primitives) that may be strategically merged according to patient specific design constraints. In particular, for bone, mechanical characteristics such as the regional stiffness in a continuum sense, micro-architectural levels of mechanical surface strain, void fraction amount and orientation, as well as permeability are critical both individually and in concert. As the influences of these factors are elucidated, the potential to successfully engineer scaffolds improves. Here we expound upon previous research of creating assembled scaffolds from derived analytical shapes, and extend it to encompass the native architecture of human trabecular bone. Architectures were derived from repeated patterns witnessed in the interior portion of various cadaveric T-9 vertebral bodies. We introduce a library in which the apparent properties, independent of tissue material properties, may be matched in a patient/site specific manner, yet the architecture maintains much of the same tissue level shape (porosity, permeability) that are essential for its biological functionality. Multiple architectural configurations with similar elastic properties are possible via the joining of the architectures using a characterized set of interfaces resulting in a global assembly constructed from a regional bone density map.