advertisement

Articular Cartilage Repair

50 %
50 %
advertisement
Information about Articular Cartilage Repair
Health & Medicine

Published on March 16, 2009

Author: akspar

Source: slideshare.net

Description

A presentation on Articular Cartilage Repair for my Functional Anatomy Course. The presentation was short as we were limited to 6 slides.

I hope you find the information of some use.
advertisement

Rebuilding from the ground up.

 Anti-inflammatory Medication or Systemic Steroids  Injections  Corticosteroids  Hyaluronic Acid  Surgery (major types)  Bone Marrow Stimulation (e.g. Microfracture)  Mosaicplasty  Surgery combined with tissue engineering (e.g. Autologous Chondrocyte Implantation (ACI))

 Growth Factors  The transforming growth factor beta (TGF-β) superfamily, specifically the BMPs, CDMPs, OPs, and GDFs, have a dramatic effect on the development of bone and cartilage tissue.  These growth factors help produce an extracellular matrix that can withstand extreme loading conditions in the body.  Mechanical Loading  Load-bearing tissue, such as articular cartilage, will atrophy in the absence of mechanical forces

Design Criteria Types Advantages • Biocompatibility • Natural • deliver the repair materials to the site of injury • Limit immune reaction responses • Fibrin • Induce maturation and • Agarose and Alginate • remain in place long enough to differentiation of cellular effect repair • Collagen structures that they are to • Chitosan • provide an even distribution of support • Hyaluronan implanted cells • Biodegrade into non-harmful substances • provide an instructive three • Synthetic dimensional environment for • Polylactic Acid (PLA) seeded and colonising cells • Structural integrity & • Polyglycolic acid (PGA) stability • allow for the controlled local • PLA-PGA Copolymer delivery of polypeptide or chemical molecules that • Durability stimulate repair • the ability of the scaffold to be retained at the implantation site

1. Frenkel, S, & Di Cesare, P. (2004) ‘Scaffolds for Articular Cartilage Repair’ Annals of Biomedical Engineering, Vol. 32, No. 1, pp. 26–34. 2. Steinert, A et al. (2007) ‘Major biological obstacles for persistent cell-based regeneration of articular cartilage’, Arthritis Research & Therapy, Vol. 9, No. 3, pp. 213-228. 3. Bhosale, A, & Richardson, J. (2008) ‘Articular cartilage: structure, injuries and review of management’, British Medical Bulletin, No. 87, pp. 77-95. 4. Darling, E, & Athanasiou, K. (2003) ‘Biomechanical Strategies for Articular Cartilage Regeneration’, Annals of Biomedical Engineering, Vol. 31, No. 9, pp. 1114–1124. 5. Marcacci, M et al (2005) ‘Articular cartilage engineering with Hyalograft C: 3-year clinical results’, Clinical orthopaedics and related research, No. 435, pp. 96–105. 6. Khan, I et al (2008) ‘Cartilage integration: evaluation of the reasons for failure of integration during cartilage repair. A review’, European cells and materials, Vol. 16, pp. 26-39 7. Ma, C (2008) ‘Cartilage Injury and repair: Current treatment of cartilage injuries’, Google Knol, [Online] Accessed on September 1 2008, Available from: http://knol.google.com/k/c-benjamin-ma/cartilage-injury-and- repair/uOR7Q0inq/hpms2a# 8. Pavesio A, et al. (2003) ‘Hyaluronan-based scaffolds (Hyalograft C) in the treatment of knee cartilage defects: preliminary clinical findings.’, Novartis Found Symp, No. 249, pp. 203—17

Add a comment

Related presentations

Related pages

Articular cartilage repair - Wikipedia, the free encyclopedia

Different articular cartilage repair procedures. Though the different articular cartilage procedures differ in the used technologies and surgical ...
Read more

ICRS - International Cartilage Repair Society | Advancing ...

Advancing science & education in cartilage repair worldwide! The society envisages the scientific research and the exchange of knowledge among physicians ...
Read more

Cartilage Health - Articular Cartilage Repair Surgery

Articular Cartilage Repair of the Knee Mention knee cartilage to most people and they will tend to think about the wedge shaped shockabsorbers of the knee ...
Read more

Articular Cartilage Restoration-OrthoInfo - AAOS

Articular cartilage is the smooth, white tissue that covers the ends of bones where they come together to form joints. Healthy cartilage in our joints ...
Read more

Articular cartilage damage - Wikipedia, the free encyclopedia

Articular cartilage damage in the knee may be found on its ... Articular Cartilage Repair of the ... The best tool for diagnosing articular damage is the ...
Read more

cartilagerepaircenter: What is cartilage repair?

What is cartilage and cartilage damage? Cartilage (hyaline cartilage or articular cartilage) is a 3-5 mm thin tissue that coats the boney surfaces inside ...
Read more

Cartilage damage - NHS Choices - NHSChoices Home Page

Cartilage damage is a relatively common type of injury. The majority of cases involve damage to the articular cartilage in the knee joint.
Read more

Articular Cartilage Damage and Repair - Chester Knee ...

Chester Knee Clinic specialises in Knee Arthroscopic Surgery, Articular Cartilage Repair, Ligament Reconstruction and Joint Replacement.
Read more

The Role of Tissue Engineering in Articular Cartilage ...

Articular cartilage repair and regeneration continue to be largely intractable due to the poor regenerative properties of this tissue. The field of ...
Read more

Articular Cartilage Repair - Noyes Knee Institute

Surgical Advances in Articular Cartilage. A Common Problem. Damage to the articular cartilage of the knee through injury (post-traumatic arthritis) or ...
Read more