Articular Cartilage Repair

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Information about Articular Cartilage Repair
Health & Medicine

Published on March 16, 2009

Author: akspar



A presentation on Articular Cartilage Repair for my Functional Anatomy Course. The presentation was short as we were limited to 6 slides.

I hope you find the information of some use.

Rebuilding from the ground up.

 Anti-inflammatory Medication or Systemic Steroids  Injections  Corticosteroids  Hyaluronic Acid  Surgery (major types)  Bone Marrow Stimulation (e.g. Microfracture)  Mosaicplasty  Surgery combined with tissue engineering (e.g. Autologous Chondrocyte Implantation (ACI))

 Growth Factors  The transforming growth factor beta (TGF-β) superfamily, specifically the BMPs, CDMPs, OPs, and GDFs, have a dramatic effect on the development of bone and cartilage tissue.  These growth factors help produce an extracellular matrix that can withstand extreme loading conditions in the body.  Mechanical Loading  Load-bearing tissue, such as articular cartilage, will atrophy in the absence of mechanical forces

Design Criteria Types Advantages • Biocompatibility • Natural • deliver the repair materials to the site of injury • Limit immune reaction responses • Fibrin • Induce maturation and • Agarose and Alginate • remain in place long enough to differentiation of cellular effect repair • Collagen structures that they are to • Chitosan • provide an even distribution of support • Hyaluronan implanted cells • Biodegrade into non-harmful substances • provide an instructive three • Synthetic dimensional environment for • Polylactic Acid (PLA) seeded and colonising cells • Structural integrity & • Polyglycolic acid (PGA) stability • allow for the controlled local • PLA-PGA Copolymer delivery of polypeptide or chemical molecules that • Durability stimulate repair • the ability of the scaffold to be retained at the implantation site

1. Frenkel, S, & Di Cesare, P. (2004) ‘Scaffolds for Articular Cartilage Repair’ Annals of Biomedical Engineering, Vol. 32, No. 1, pp. 26–34. 2. Steinert, A et al. (2007) ‘Major biological obstacles for persistent cell-based regeneration of articular cartilage’, Arthritis Research & Therapy, Vol. 9, No. 3, pp. 213-228. 3. Bhosale, A, & Richardson, J. (2008) ‘Articular cartilage: structure, injuries and review of management’, British Medical Bulletin, No. 87, pp. 77-95. 4. Darling, E, & Athanasiou, K. (2003) ‘Biomechanical Strategies for Articular Cartilage Regeneration’, Annals of Biomedical Engineering, Vol. 31, No. 9, pp. 1114–1124. 5. Marcacci, M et al (2005) ‘Articular cartilage engineering with Hyalograft C: 3-year clinical results’, Clinical orthopaedics and related research, No. 435, pp. 96–105. 6. Khan, I et al (2008) ‘Cartilage integration: evaluation of the reasons for failure of integration during cartilage repair. A review’, European cells and materials, Vol. 16, pp. 26-39 7. Ma, C (2008) ‘Cartilage Injury and repair: Current treatment of cartilage injuries’, Google Knol, [Online] Accessed on September 1 2008, Available from: repair/uOR7Q0inq/hpms2a# 8. Pavesio A, et al. (2003) ‘Hyaluronan-based scaffolds (Hyalograft C) in the treatment of knee cartilage defects: preliminary clinical findings.’, Novartis Found Symp, No. 249, pp. 203—17

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