Anti depressants - introduction and mechanism of action

67 %
33 %
Information about Anti depressants - introduction and mechanism of action

Published on June 27, 2014

Author: lolaeldardiry



An introduction to the different types of anti depressants and their mechanism of actions.

Introduction and mechanism of action By : Ola S. Eldardiry

Anti depressants Psychiatric medications given to patients with depressive disorders to alleviate symptoms. Types: 1. Monoamine oxidase inhibitors (MAOIs) 2. Noradrenaline and specific serotoninergic antidepressants (NASSAs) 3. Serotonin and noradrenaline reuptake inhibitors (SNRIs) 4. Selective serotonin reuptake inhibitors (SSRIs) 5. Tricyclics (TCAs) Onset: delayed up to few weeks. Duration of treatment: few months or several years Serious problem = lack of compliance

Uses • Agitation • Obsessive compulsive disorders (OCD) • Childhood enuresis (bedwetting) • Depression • Generalized anxiety disorder • Major depressive disorder • Manic-depressive disorders • Posttraumatic stress disorder (PTSD) • Social anxiety disorder Primary (approved)

• Binge eating disorder • Bulimia nervosa • Chronic urticaria (hives) • Fibromyalgia • Osteoarthritis pain • Hot flashes • Diabetic peripheral neuropathic pain • Neuropathic pain • Hyperhidrosis (drug-induced) • Premenstrual symptoms • Tourette syndrome • Ruritus (itching) • Migraines • Snoring “Off-label” – unapproved indication

Mechanism of action Monoamine Oxidase Inhibitors (MAOIs)

Tricyclic Antidepressants (TCAs)

Selective Serotonin Reuptake Inhibitors (SSRIs)

Serotonin/ Norepinephrine/ Dopamine Reuptake Inhibition (SNRI) (Venlafaxine)

On comparison with SSRI: • 5-HT2 receptors are blocked • Don’t cause some side effects such as: • Short-term increase in anxiety or insomnia • Akathisia • Sexual dysfunction Serotonin-2 Receptor Antagonism with Serotonin Reuptake Blockade (Nefazodone, Trazodone)

Norepinephrine and Dopamine Reuptake Inhibition (Bupropion)

α-2 Antagonism plus Serotonin-2 and Serotonin-3 Antagonism (Mirtazapine)

Noradrenalin Specific Reuptake Inhibitor (NRI) (Reboxetine)

Serotonin Reuptake Enhancer (Tianeptine) • Tricyclic compound of diabenzothiazepine type • Increases presynaptic uptake of serotonin after single + repeated administration • Not linked to any effects on 5-HT post-synaptic systems • No affinity for: o α1 adrenergic o H1 antihistaminic o Muscarinic receptors • Similar to TCAs but with faster onset • Not stimulating nor sedative • No anticholinergic effect • No cardiovascular effect

Add a comment

Related pages

Mechanism of Action of SSRIs - Psychopharmacology Institute

1.1 Introduction; 1.2 The monoamine ... In the next slides we’ll be discussing the mechanism of action of selective serotonin reuptake inhibitors, or ...
Read more

Pharmacology of antidepressants - Wikipedia

The pharmacology of antidepressants is not ... it was revived with the introduction of SSRIs through the ... a putative mechanism of action of ...
Read more

Mechanism of Actions of Antidepressants: Beyond the Receptors

Mechanism of Actions of Antidepressants: ... Introduction S ... The mechanism of action of an MAOI is to increase
Read more

The mechanisms of tolerance in antidepressant action

Introduction. The possibility that ... supports the concept of an antidepressant mechanism of action that exerts its effects beyond the cell membrane ...
Read more

Antidepressants : mechanisms of action

... in depression and the mechanism involved in antidepressant action. ... The latest development has been the introduction of the noradrenergic and ...
Read more


ANTIPSYCHOTICS AS ANTIDEPRESSANTS: WHAT IS THE MECHANISM? ... INTRODUCTION Antidepressants are ... add-on treatment of ziprasidone to anti-depressants was ...
Read more

Antidepressants - NHS Choices

Introduction . Antidepressants are a type of medication used to treat clinical depression or prevent it recurring. They can also be used to treat a number ...
Read more