All about Cholesterol ( for undergrads)

71 %
29 %
Information about All about Cholesterol ( for undergrads)
Health & Medicine

Published on February 3, 2014

Author: abhishekdahal



It is an explanatory slide for Undergraduates student wanting to know about cholesterol , its metabolism in a brief and technical way.

Cholesterol and Compounds AD

Cholesterol Def: It is a steroid alcohol of animal tissue having 27 Carbon units, which performs essential functions in body. Normal Blood Cholesterol: 150-250 mg/dl  Liver has a central role in regulating blood cholesterol level.

CHOLESTEROL SYNTHESIS, TRANSPORT, AND EXCRETION   A little more than half the cholesterol of the body arises by synthesis (about 700 mg/d), and the remainder is provided by the average diet. The liver accounts for 10% of total synthesis in humans, the intestine for about another 10%. Microsomal (endoplasmic reticulum) and cytosol fraction of the cell is responsible for cholesterol synthesis.

HMG CoA Reductase (More Than Cholesterol Synthesis) 3Acetyl CoA (2C) HMG CoA(6C) HMG CoA Reductase Mevalonate Prenylation of signalling peptides (ras, rho, etc.) Isopentenyl adenine (transfer RNA) Farnesyl Pyrophosphate Dolichols Cholesterol Inhibition of other key products of mevalonate may relate to nonlipid effects & rare side effects of statins.

Regulation 1. Dietary Cholesterol: Increase in Dietary 2. Feed-back Control: Increase in Cholesterol 3. cholesterol Causes Decrease in Denovo synthesis. causes Inhibition of HMGCoA Reductase synthesis (regulation of gene expression) and Inactivation of Remaining enzymes Liver: a) By LCAT mechanism b) Bile acids/salts c) Incorporation into VLDL

Metabolic Fates of Cholesterol Steroid Hormones Vitamin D Cholesterol Incorporation into Biological Membranes Bile Acids

Types of Bile Acids/Salts  Primary bile acids  Good emulsifying agents    All OH groups on same side pKa = 6 (partially ionized) Conjugated bile salts   Amide bonds with glycine or taurine Very good emulsifier  pKa lower than bile acids

Recycling of Bile Acids  Enterohepatic circulation  98% recycling of bile acids

Steroid Hormone Metabolism: Adrenal Steroid Hormones  Aldosterone    C21 derivative of cholesterol Promotes renal Sodium retention   Glucocorticoids (cortisol)  Starvation     Potassium excretion Hepatic gluconeogenesis Muscle protein degradation Adipose lipolysis Adrenal androgens  Dehydroepiandroterone (DHEA)  Precurser to potent androgens in extraadrenal tissues

Add a comment

Related presentations

Related pages

L-tyrosine Cholesterol Mayo Test Clinic Alaska Juneau

All about Cholesterol ( for undergrads) Presentation Transcript. L-tyrosine Cholesterol Mayo Test Clinic Alaska Juneau what is the relationship between ...
Read more

Campus Life | Johns Hopkins University

We have 24 varsity sports teams, and more than half of our undergrads play intramural or club sports. ... All this takes place in Baltimore, ...
Read more

How Undergrads Make Doctors Wash Their Hands - Health Blog ...

The trick was getting undergrads to volunteer to ... View all Comments » 6:02 pm ... of Boston concluded that the high cholesterol levels ...
Read more

Tax sugary sodas and snacks, but don't sweat cholesterol ...

... though they no longer need to worry about cholesterol, ... more than 10 percent of all ... female undergrads experience ...
Read more

Rabbit Diets Were Just for Starters - latimes

More than 500 undergrads from ... For Cal State L.A. student Maira Soto, it's all ... "The Influence of Dietary Jojoba Oil on Cholesterol ...
Read more

Q&A: What you need to know about new cholesterol ...

The nation's top diet panel has decided to downgrade the alarm about cholesterol ... undergrads at top schools suffer ... new cholesterol ...
Read more

Community Pharmacist Job Description | AllAboutCareers

Swing by and tell us all about the ... The primary responsibility of a community pharmacist is to dispense ... check cholesterol and ...
Read more

Section 1: The evolution of cells and the molecules of life

than designed. This implies that all cell types present today gained their current structure by ... Cholesterol molecules and protein molecules ...
Read more