advertisement

Aging Presentation - Ian Deary [30 NOV 2

33 %
67 %
advertisement
Information about Aging Presentation - Ian Deary [30 NOV 2
Entertainment

Published on December 22, 2008

Author: aSGuest7664

Source: authorstream.com

advertisement

The role of genes and genetics in cognitive ageingIan Deary : The role of genes and genetics in cognitive ageingIan Deary Cognitive ageing: The big problem : Cognitive ageing: The big problem “The retiring editor of a leading journal identified ‘The Top 10 Hot Topics In Aging’. Cognitive decline was the first topic on his list. It is the single most feared aspect of growing old.” George M. Martin (2004) Nature, 431, 247-248 “For many aging people cognitive decline is the main threat to their ability to continue enjoying their favourite activities.” USA National Research Council (2000) The Aging Mind. Genetics and cognitive ageing: ten points : Genetics and cognitive ageing: ten points Human cognitive abilities have a hierarchical structure Human cognitive ability differences are partly heritable Heritability changes with age Heritability might vary with social background Heritability mostly concerns the g factor Human cognitive ageing varies according to ability domain Human cognitive ageing substantially concerns the g factor Human cognitive ageing substantially concerns speed Individual differences in human cognitive ageing Identification of genes influencing cognitive ageing differences Slide 4: Deary (2001) Trends in Cognitive Sciences, 51, 127-130. Deary (2001) Trends in Cognitive Sciences, 5, 127-130. Human cognitive abilities have a hierarchical structure Slide 5: Plomin & Spinath (2004) Journal of Personality and Social Psychology, 86, 112–129 Human cognitive ability differences are partly heritable Slide 6: “When data across all studies are collapsed, genetic influences [on intelligence differences] account for around 50% of the variance” Petrill et al. (2004) Developmental Psychology, 40, 805-812. Human cognitive ability differences are partly heritable Slide 7: Bouchard & McGue (2003) Journal of Neurobiology, 54, 4-45. Heritability changes with age IQ variance component estimates derived from published IQ twin correlations (from McGue et al., 1993). Slide 8: Bouchard & McGue (2003) Journal of Neurobiology, 54, 4-45. Estimates of genetic (h2) and shared environmental (c2) variance for IQ by age for Dutch samples. Genetic and environmental effects on IQ change with age Heritability might vary with social background : Heritability might vary with social background Turkheimer et al. (2003) Psychological Science, 14, 623-628. Heritability mostly concerns the g factorDutch Twin Study : Heritability mostly concerns the g factorDutch Twin Study Rijsdijk et al. (2002) Behavior Genetics, 32, 199-210. A = additive genetic effects; g = general intelligence vc = verbal comprehension; fd = freedom from distraction; po = perceptual organisation Heritability mostly concerns the g factorSwedish Octo Twin Project : Petrill et al. (1998) Psychological Science, 9, 183-189. “the same genetic influences were operating across different specific cognitive abilities” (p. 187) Heritability mostly concerns the g factorSwedish Octo Twin Project Slide 12: Hedden & Gabrieli (2003) Nature Reviews Neuroscience, 5, 87-96. Human cognitive ageing varies according to ability domain Seattle Longitudinal Study Slide 13: Verhaeghen & Salthouse (1997) Psychological Bulletin, 122, 231. Human cognitive ageing substantially concerns the g factor Meta-analysis of 91 studies of age & cognition in adulthood Slide 14: Human cognitive ageing substantially concerns speed Slide 15: Age 80 Age 20 Half a second One second Deary & Der (in press) Psychology and Aging Human cognitive ageing substantially concerns speed Slide 16: Individual differences in human cognitive ageing Taking the same IQ test at age 11 & age 80: Scottish Mental Survey 1932 Deary et al. (2004) Journal of Personality and Social Psychology, 86, 130-147. Slide 17: Deary et al. (2002) Nature, 418, 932. Identification of genes influencing cognitive ageing Scottish Mental Survey 1932 Identification of genes influencing cognitive ageing : Identification of genes influencing cognitive ageing Genes related to dementia Genes related to intelligence, memory, executive function etc. Genes related to oxidative stress Genes related to longevity & ageing Genes related to cardiovascular disease Telomeres Whole genome analyses Effect sizes Sample sizes & nature of samples (biobanks) Deary et al. (2004) Trends in Cognitive Sciences, 8, 178-184. Identification of genes influencing cognitive ageingScottish Mental Survey follow up : Identification of genes influencing cognitive ageingScottish Mental Survey follow up NSL = Neuroscience Letters Effect sizes small; replication needed (APOE well replicated) Clues to ‘successful’ cognitive ageing? : Clues to ‘successful’ cognitive ageing? Genes: only a few known Health (no cardiovascular disease, diabetes, etc) Blood pressure Nutrition Fewer white matter lesions in the brain Not smoking Intellectual engagement Social engagement Physical exercise But physical basis of cognitive ageing not understood Efficiency of brain processing?; connections? The role of genes and genetics in cognitive ageing : The role of genes and genetics in cognitive ageing Ian Deary Department of Psychology University of Edinburgh 7, George Square Edinburgh EH8 9JZ I.Deary@ed.ac.uk

Add a comment

Related presentations

Related pages

Aging - cognition, imaging and genetics - Google Sites

" Aging - cognition, imaging and genetics ": ... 2014 Apr 30;222(1-2) ... Ian Deary, William Hill, ...
Read more

Rediscovered data confirm link between early intellect and ...

... and a lower risk for dementia in old age. Whalley, Deary and colleagues ... function and dementia during aging. ... (2) Presentation (2 ...
Read more

Neurobiology of Cognitive Aging: Insights from Imaging ...

In their seminal review of cognitive aging, Deary, ... the neurobiology of cognitive aging. Ageing Res Rev. 2004 Nov; 3 ... Sci U S A. 2001 Jan 2; 98 ...
Read more

Business world map template - Presentation Magazine ...

Posted by Jonathan — 13 Jan @ 2:19 ... Posted by rickie — 30 Nov @ 1:40 ... useful and effective in business presentations. Posted by laura — 9 Jan ...
Read more

AgingWatch: The Link to Policy Affecting Older Iowans ...

Iowa Department on Aging; ... AgingWatch: The Link to Policy Affecting Older Iowans. 2015. ... Jan. 25. Jan. 18. 2012. Nov. 30. Sept. 28. July 27.
Read more

Business 1 - Presentation Magazine - 54,294 free ...

Posted by Jonathan — 13 Jan @ 2:20 pm . ... Posted by robinho — 30 Nov @ 8:58 am . ... Very sober and sophisticated. ideal for a business presentation.
Read more

Facebook - Log In or Sign Up

Create an account or log into Facebook. Connect with friends, family and other people you know. Share photos and videos, send messages and get updates.
Read more

Normal Brain Development and Aging: Quantitative Analysis ...

1 From the Laboratory for Research on the Neuroscience of Autism, Children’s Hospital Research Center, 8110 La Jolla Shores Dr, Suite 201, La Jolla, CA ...
Read more