A Review of Inclusion body hepatitis-hyd

40 %
60 %
Information about A Review of Inclusion body hepatitis-hyd
Education

Published on July 16, 2009

Author: kedarkarki

Source: authorstream.com

A Review of Inclusion body hepatitis-hydropericardium syndrome (IBH-HPS) and Emergence of Hydropericardium Syndrome in Broilers of Chitwan Nepal : A Review of Inclusion body hepatitis-hydropericardium syndrome (IBH-HPS) and Emergence of Hydropericardium Syndrome in Broilers of Chitwan Nepal Dr.Kedar Karki,Dr.Subir Singh Slide 2: IBH/HPS is an acute infectious disease characterized by typical hydropericardium, severe anaemia, necrotic hepatitis and high mortality. In natural outbreaks, the affected birds may not exhibit any clinical signs (Jaffery, 1988) except sudden heavy mortality (Ravikumar et al., 1997). Mortality rates in various outbreaks range from 15- 60% (Asrani et al., 1997). Slide 3: Inclusion body hepatitis-hydropericardium syndrome (IBH-HPS), also known as "litchi disease", is a common disease of broiler chicken (Cheema et al., 1989) caused by fowl adenoviruses of serotype 4. The disease mostly affects young birds between 3 and 6 weeks of age (Niazi et al., 1989) and occasionally layer and breeder pullets also. Rarely the disease has been reported from older broilers, (Asrani et al., 1997) or in other species of birds like pigeon (Naeem and Akram, 1995). Slide 4: Litchi Heart disease, primarily of broiler chickens, was first reported in Angara Goth near Karachi, Pakistan, during 1987 (Khawaja et al., 1988; Gowda and Satyanarayana, 1994), and it has been reported to be particularly important in some countries in Asia and America (Jaffery, 1988; Shane, 1996; Abe et al., 1998). Slide 5: Emergence of “Hydropericardium Syndrome” in Broilers of Chitwan In the month of June and July 2009, the veterinarians of Chitwan have experienced an emergence of Hydropericardium Syndrome in Broilers. The disease is showing the high spread rate with high morbidity and mortality pattern. The disease has been reported from Navalparashi, Chitwan and Makwanpur. Epidemiological Status:Chitwon Nepal : Epidemiological Status:Chitwon Nepal • Occurs usually in 3 to 5 wks old broiler • Mortality is 2 to 5 % daily and morbidity is more than 30 % • Mostly chicks with identified origin (imported from India) through different dealers. But some Nepalese hatchery sources are also identified. • The cases recorded at VTH (IAAS) Rampur, NAL, Bharatpur and by several field veterinarians reveals that the disease is in increasing trend. SPORADIC CASES REPORTED IN Central veterinary Laboratory Kathmandu also Symptoms: : Symptoms: Sudden onset of mortality, dullness, huddling together, ruffled feathers and mucoid/ yellowish dropping Postmortem Findings: : Postmortem Findings: • Fluid in the pericardial sac (‘Hydropericardium’), pin point haemorrhage on pericardium. • Congestion of lungs. • Liver and Kidney : Enlarged, pale and friable. • Enteritis Slide 9: FAV-4 is a highly pathogenic virus (Khawaja et al., 1988) spreading readily from flock to flock and from farm to farm (Cowen, 1992), transmitted horizontally (Aktar, 1995) by oro-faecal route (Abdul-Aziz and Hassan, 1995). Slide 10: The disease may be suspected based on characteristic gross lesions, with high mortality, among broiler chicks of 3-6 weeks of age (Ravi Kumar et al., 1997). A characteristic gross lesion is hydropericardium, occurring in more than 90% of the affected birds (Anjum et al., 1989). Slide 11: The liver may be pale yellow, swollen, friable/mottled with large areas of focal necrotic patches (Ravikumar et al., 1997). Abdul-Aziz and Hasan (1995) reported the presence of gross lesions in liver and kidneys and microscopic lesions in liver, kidneys, bursa and spleen. Hydropericardium : Hydropericardium Hydropericardium : Hydropericardium Haemorrhage on pericardium : Haemorrhage on pericardium chick with IBH/HPS showing characteristic hydropericardium and hepatitis. : chick with IBH/HPS showing characteristic hydropericardium and hepatitis. Leechi disease hydropericardium : Leechi disease hydropericardium Leechi disease : Leechi disease Slide 19: Histopathological lesions, particularly the demonstration of characteristic basophilic intranuclear inclusion bodies in hepatocytes, necrotic hepatitis, oedematous and congested lungs, interstitial nephritis with urate deposition and focal haemorrhages in kidneys help in tentative diagnosis. Liver: Hepatocytes showing basophilic intranuclear inclusion bodies. (H & E × 400) : Liver: Hepatocytes showing basophilic intranuclear inclusion bodies. (H & E × 400) Slide 21: The demonstration of adenoviral particles in the nucleus of infected cells by transmission electron microscopy (Chandra et al., 1997) can conclusively prove the aetiology. Slide 22: Immunodiagnosis can be performed by employing serological tests such as gel diffusion, indirect haemagglutination test, immunoperoxidase and ELISA (Noor-ul-Hassan et al., 1994; Oberoi et al., 1996; Nagal et al., 1990; Saifuddin and Wilks, 1991), which are considered to be specific and reliable. Group specificity can be confirmed with an immuno-fluorescence assay (Adair et al., 1980) whereas neutralization test has been employed to determine the exact serotype (Grimes and King, 1977; Monreal et al., 1980). References : References Indian Journal of Comparative Microbiology, Immunology and Infectious DiseasesYear : 2003, Volume : 24, Issue : 2:Application of polymerase chain reaction and fluorescent antibody technique for the diagnosis of inclusion body hepatitis-hydropericardium syndrome (IBH-HPS) caused by fowl adenovirus serotype-4 Rahul,S.,Kataria.J.M.,Kumar.N. Senthil,Dhama.K.,Dash.B.B.,Uma.R.,Praveen.B.N. Division of Avian Diseases, Indian Veterinary Research Institute, Izatnagar - 243122 (U.P.) Emergence of Hydropericardium Syndrome in Broilers of ChitwanReported by, Dr. Subir Singh General Secretary Nepal Veterinary Association.E-mail: subirsingh@hotmail.com Slide 24: THANK YOU

Add a comment

Related presentations

Related pages

Inclusion Body Disease, A Worldwide Infectious Disease of ...

Inclusion Body Disease, ... inclusion protein in small amounts ... sion body disease in snakes: a review and description
Read more

Inclusion bodies - Wikipedia, the free encyclopedia

Inclusion bodies, sometimes called ... Protozoan Inclusion. Malaria; Babesia; Inclusion bodies in Bacteria ... Councilman body; Tzanck test; Inclusion ...
Read more

Inclusion body myositis - Wikipedia, the free encyclopedia

Inclusion body myositis ... See hereditary inclusion body myopathy. A 2007 review that summarized current understanding of the contribution of genetic ...
Read more

Inclusion Body Myositis and Doctor - Reviews

Learn what other patients are saying about Inclusion Body Myositis and Doctor.
Read more

Inclusion Body Myositis (IBM) - Pipeline Review, H2 2015 ...

Inclusion Body Myositis (IBM) - Pipeline Review, H2 2015. About Us; Contact Us; Sitemap; Home; Our Services. Market Research Reports; ... Inclusion Body ...
Read more

REVIEW ARTICLES Protein aggregation: A perspective from ...

Protein aggregation: A perspective from ... This review aims to summarize the knowledge gained in ... inclusion body and amyloid formation.
Read more

TE I - European Agency for Special Needs and Inclusive ...

TEACHER EDUCATION FOR INCLUSION International Literature Review European Agency for Development in Special Needs Education
Read more

Inclusion Body Myositis (IBM) - Pipeline Review, H1 2015 ...

Number of Products under Development for Inclusion Body Myositis (IBM), H1 2015 7 Number of Products under Development for Inclusion Body Myositis (IBM ...
Read more