2007 apiii obx

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Published on December 6, 2007

Author: Lilly

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Slide1:  Oncologic Pathology in Biomedical Terminologies Challenges for Data Integration Olivier Bodenreider National Library of Medicine Bethesda, Maryland - USA Anita Burgun Medical School / Univ. Hospital University of Rennes, France Motivation:  Motivation Multiple terminologies for oncology International Classification of Diseases-Oncology (ICD-O-3) Cancer registries Epidemiology, Public health SNOMED CT Patient records Clinical care NCI Thesaurus Annotation of research data SNOMED CT:  SNOMED CT http://www.clinical-info.co.uk/ NCI Thesaurus:  NCI Thesaurus ICD-O-3:  ICD-O-3 Morphology […] 814-838 Adenomas and adenocarcinomas 8140/3 Adenocarcinoma, NOS Anatomy […] C60-C63 Male genital organs C61 Prostate gland C61.9 Prostate, NOS Prostate gland Adenocarcinoma of prostate Integrating subdomains:  Integrating subdomains ICD-O NCI Thesaurus SNOMED CT Terminology integration NCI Metathesaurus:  Terminology integration NCI Metathesaurus ICD-O NCI Thesaurus SNOMED CT NCI Meta. Objective Assess consistency:  Objective Assess consistency ICD-O NCI Thesaurus SNOMED CT Objective Assess consistency:  Objective Assess consistency Neoplasm concepts present in the 3 terminologies Relationship to Anatomy concept Relationship to Morphology concept For a given neoplasm, consistency among Anatomy concepts Morphology concepts Preliminary, proof-of-concept study Qualitative analysis of some cases in the 3 terminologies Results Major types of issues:  Results Major types of issues Missing relationships For Morphology (e.g., not relationship to Morphology concepts in the NCI Thesaurus for Adenocarcinoma of prostate) Confusion between Morphology and Disease concepts In the NCI/UMLS Metathesaurus (e.g., Renal cell carcinoma vs. Adenocarcinoma of kidney) Granularity issues Anatomy concept express at different levels of granularity for the same neoplasm concept in different terminologies) Missing relationship to Morphology concept:  Missing relationship to Morphology concept Results Major types of issues:  Results Major types of issues Missing relationships For Morphology (e.g., not relationship to Morphology concepts in the NCI Thesaurus for Adenocarcinoma of prostate) Confusion between Morphology and Disease concepts In the NCI/UMLS Metathesaurus (e.g., Renal cell carcinoma vs. Adenocarcinoma of kidney) Granularity issues Anatomy concept express at different levels of granularity for the same neoplasm concept in different terminologies) Confusion between Morphology and Disease:  Confusion between Morphology and Disease ICD-O NCI Thesaurus SNOMED CT NCI Meta. Renal cell carcinoma (41607009) C0007134 Clear cell carcinoma of kidney (254915003) Results Major types of issues:  Results Major types of issues Missing relationships For Morphology (e.g., not relationship to Morphology concepts in the NCI Thesaurus for Adenocarcinoma of prostate) Confusion between Morphology and Disease concepts In the NCI/UMLS Metathesaurus (e.g., Renal cell carcinoma vs. Adenocarcinoma of kidney) Granularity issues Anatomy concept express at different levels of granularity for the same neoplasm concept in different terminologies) Conclusions:  Conclusions Integrating biomedical information from clinical care, research and epidemiology remains challenging Oncology terminologies are not always consistent Shared codes and mappings between terminologies help assess consistency and suggest corrections when needed

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