13 HB - pH DPG NARRATED v2

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Published on March 9, 2014

Author: dylankerber

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Lecture 13 : Hb / pH, DPG, mutations: Lecture 13 : Hb / pH, DPG, mutations PowerPoint Presentation: Figures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5th Edition, published (2009) by the Custom Services division of John Wiley and Sons, Inc. (Hoboken, NJ). Some figures might be taken from the textbooks listed below. This material is used by permission of John Wiley & Sons, Inc. Fundamentals of Biochemistry, 1 st and 2 nd editions (©1999 and 2006, Wiley) D. Voet, J.G. Voet, & C.W. Pratt Biochemistry, 3 rd edition (© 2004, Wiley) D. Voet & J.G. Voet Principles of Anatomy and Physiology, 10 th edition (© 2003, Wiley) G.J. Tortora & S.R. Grabowski Essential Biochemistry, 3rd edition (© 2004, Wiley) C.W. Pratt & K. Cornely Cell Biology, 4th edition (© 2005, Wiley) Karp Effects of pH: Effects of pH V-01: V-01 V-01 Based on Fig 7-12, p. 195, Voet Voet & Pratt (2 nd Ed.), Wiley (2006) Higher pH = stronger binding N-01A: N-01A N-1A N-01B: N-01B N-1B arrangement N-02 : N-02 N-02* Based on Fig 10-18, p. 335, Voet & Voet (3 rd Ed.), Wiley (2004) Effects of DPG: Effects of DPG V-02: V-02 Based on Box 7-3, p. 198, Voet Voet & Pratt (2 nd Ed.), Wiley (2006) V-02 M L2 L1 q small bad large good N-03A: N-03A N-3A N-03B: N-03B N-3B N-04*: N-04* N-04* Based on Fig 10-9, p. 327, Voet & Voet (3 rd Ed.), Wiley (2004) N-05: N-05 Effects of mutations: Effects of mutations V-03: V-03 V-03 Based on Fig 7-18a, p. 201, Voet Voet & Pratt (2 nd Ed.), Wiley (2006) V-04: V-04 V-04 Based on Fig 7-20, p. 202, Voet Voet & Pratt (2 nd Ed.), Wiley (2006) N-06*: N-06* Based on Fig 10-26, p. 243, Voet & Voet (3rd Edit), Wiley (2004) N-06* beta chain : glutamic acid (COO-) mutates to valine (isopropane) V-05: V-05 V-05 Based on Fig 7-15, p. 197, Voet Voet & Pratt (2 nd Ed.), Wiley (2006) mother : beta histidine 143 + fetus : gamma serine 143 N-07*: N-07* N-07* Based on Fig 23-23, p. 834, Tortora & Grabowski (10 th Ed.), Wiley (2003) N-08 : N-08 N-08

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